Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.50 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195017 | 0.89 | MAPK1 (0.60) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2854348 | 0.83 | RAB9A (0.54) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL10969941 | 0.81 | RIPK2 (0.58) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2861261 | 0.80 | HPGD (0.64) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5325459 | 0.78 | ALDH1A1 (0.53) | MAPK1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL2848335 | 0.78 | ATM (0.54) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2852350 | 0.78 | NPC1 (0.53) | MAPK1RAB9ANPC1MAPTHPGD | |
| SCHEMBL2854815 | 0.78 | MEN1 (0.50) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2852507 | 0.77 | NPC1 (0.51) | RAB9ANPC1MAPTSMN1; SMN2NFKB1 | |
| SCHEMBL14989237 | 0.77 | MAPK13 (0.44) | MAPK1RAB9ANPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |