Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205230 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL11660830 | 0.84 | CA1 (0.47) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL1512735 | 0.80 | PBRM1 (0.47) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL31591225 | 0.80 | PBRM1 (0.47) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL11659662 | 0.74 | L3MBTL1 (0.43) | PTGS2PTGS1L3MBTL1ALDH1A1 | |
| SCHEMBL6206980 | 0.73 | CASP1 (0.50) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL31511760 | 0.73 | PBRM1 (0.41) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL21962019 | 0.73 | PBRM1 (0.41) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL2907226 | 0.73 | PBRM1 (0.41) | PTGS2PTGS1PBRM1CASP1CASP7 | |
| SCHEMBL5200589 | 0.73 | HSD17B1 (0.44) | PTGS2PTGS1PBRM1CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098891-B1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1098891-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6159996-A | Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| WO-2000004006-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |
| US-4129656-A | Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-12 | — | — | US | disclosed |