Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.57 |
| ▸ | PFKFB4 | Q16877 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206630 | 1.00 | WDR5 (0.57) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6206627 | 1.00 | WDR5 (0.57) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6205309 | 0.89 | WDR5 (0.54) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6205304 | 0.89 | WDR5 (0.54) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6205307 | 0.89 | WDR5 (0.54) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6204503 | 0.86 | HSD17B1 (0.52) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6205979 | 0.86 | HSD17B1 (0.52) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6205977 | 0.86 | HSD17B1 (0.52) | WDR5PFKFB4NPC1ITGA1MEN1 | |
| SCHEMBL6205383 | 0.85 | ITGA1 (0.53) | WDR5NPC1ITGA1MEN1KMT2A | |
| SCHEMBL6205381 | 0.85 | ITGA1 (0.53) | WDR5NPC1ITGA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100763-B1 | DIKETOACID-DERIVATIVES AS INHIBITORS OF POLYMERASES | ANGELETTI P IST RICHERCHE BIO (IT) | 2005-06-22 | — | — | EP | claimed |