Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205994 | 0.89 | TDP1 (0.48) | ATMTDP1KMT2AMEN1HPGD | |
| SCHEMBL6204389 | 0.78 | ATM (0.46) | ATMTDP1MRGPRX4KMT2AMEN1 | |
| SCHEMBL6206062 | 0.77 | ATM (0.51) | ATMTDP1MRGPRX4KMT2AMEN1 | |
| SCHEMBL6204759 | 0.77 | TDP1 (0.51) | ATMTDP1KMT2AMEN1HPGD | |
| SCHEMBL6208230 | 0.77 | ATM (0.48) | ATMTDP1MRGPRX4KMT2AMEN1 | |
| SCHEMBL6206051 | 0.77 | TDP1 (0.48) | ATMTDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6206638 | 0.77 | ATM (0.48) | ATMTDP1MRGPRX4KMT2AMEN1 | |
| SCHEMBL9124237 | 0.75 | TDP1 (0.53) | ATMTDP1KMT2AMEN1HPGD | |
| SCHEMBL6204946 | 0.75 | ATM (0.49) | ATMTDP1KMT2AMEN1NPC1 | |
| SCHEMBL6206293 | 0.73 | ALDH1A1 (0.54) | ATMTDP1KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |