Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206596 | 0.90 | HDAC1 (0.55) | MAPTHDAC2HDAC8HDAC6TDP1 | |
| SCHEMBL23929240 | 0.81 | GPR52 (0.56) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL23929239 | 0.81 | GPR52 (0.56) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL14571875 | 0.79 | GPR52 (0.58) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL28945946 | 0.79 | GPR52 (0.58) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL3638330 | 0.78 | ALDH1A1 (0.62) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL17429280 | 0.76 | ALDH1A1 (0.66) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL6206996 | 0.75 | KEAP1 (0.52) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL7268052 | 0.75 | KEAP1 (0.52) | GPR52KEAP1ALDH1A1FFAR1MAPT | |
| SCHEMBL7268064 | 0.75 | KEAP1 (0.52) | GPR52KEAP1ALDH1A1FFAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |