Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 3/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033190 | 0.88 | MAPT (0.65) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL4032764 | 0.74 | MMP1 (0.62) | ALDH1A1MMP1MMP9MMP13MMP3 | |
| SCHEMBL2440987 | 0.70 | FKBP1A (0.53) | ALDH1A1MMP1MMP9MMP13MMP3 | |
| SCHEMBL7346677 | 0.70 | MMP1 (0.54) | ALDH1A1MEN1KMT2AMMP1MMP9 | |
| SCHEMBL4032527 | 0.69 | USP2 (0.60) | ALDH1A1MMP1MMP9MMP13MMP3 | |
| SCHEMBL4033188 | 0.68 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1KMT2AHTT | |
| SCHEMBL26848353 | 0.67 | L3MBTL1 (0.62) | ALDH1A1MEN1KMT2AMMP1MMP9 | |
| SCHEMBL2437981 | 0.67 | MMP1 (0.58) | ALDH1A1MMP1MMP9MMP13MMP3 | |
| SCHEMBL6237734 | 0.67 | MMP1 (0.71) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL4402232 | 0.66 | MMP1 (0.78) | MMP1MMP9MMP13MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |