Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032958 | 0.86 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4041586 | 0.75 | FKBP1A (0.41) | ALDH1A1 | |
| SCHEMBL4038466 | 0.71 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL4033190 | 0.70 | MAPT (0.65) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL6207527 | 0.68 | ALDH1A1 (0.50) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL4038075 | 0.67 | ALDH1A1 (0.47) | ALDH1A1MAPTKMT2AMEN1LMNA | |
| SCHEMBL4036533 | 0.64 | MMP3 (0.43) | ALDH1A1MAPTKMT2ALMNASMN1; SMN2 | |
| SCHEMBL17833176 | 0.63 | MMP2 (0.59) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL695071 | 0.63 | MMP2 (0.59) | ALDH1A1MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7346677 | 0.63 | MMP1 (0.54) | ALDH1A1KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |