Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | MC1R | Q01726 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.33 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212077 | 0.90 | CTSL (0.39) | POLBCTSKACEACE2CTSB | |
| SCHEMBL4049549 | 0.88 | GPR132 (0.38) | CTSKACEACE2CTSBCTSS | |
| SCHEMBL4042676 | 0.87 | CTSB (0.36) | MAPK1ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4041433 | 0.86 | ALDH1A1 (0.35) | ALDH1A1POLBCTSBCTSSMC4R | |
| SCHEMBL4047478 | 0.84 | MC4R (0.37) | CTSKACECTSBCTSSMC4R | |
| SCHEMBL4043722 | 0.84 | CTSK (0.40) | CTSKACEACE2CTSBCTSS | |
| SCHEMBL6209627 | 0.83 | CHRNB2 (0.42) | MAPTCTSKACEACE2CTSB | |
| SCHEMBL4040214 | 0.83 | GPR132 (0.39) | SMN1; SMN2CTSKACEGPR132MC4R | |
| SCHEMBL4042165 | 0.82 | EPHX1 (0.37) | CTSKACECTSBCTSSGPR132 | |
| SCHEMBL4041149 | 0.81 | ITGA4 (0.39) | ALDH1A1MAPTCTSKACEITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |