Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.35 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041149 | 0.94 | ITGA4 (0.39) | CTSKECE1ACECHRNA7MMP12 | |
| SCHEMBL4040214 | 0.94 | GPR132 (0.39) | GPR132CTSKECE1ACECHRNA7 | |
| SCHEMBL4042165 | 0.93 | EPHX1 (0.37) | GPR132CTSKECE1ACECHRNA7 | |
| SCHEMBL4045083 | 0.89 | CTSK (0.47) | CTSKCHRNA7CTSBCTSSEPHX1 | |
| SCHEMBL4047771 | 0.89 | CTSK (0.39) | GPR132CTSKECE1CHRNA7ADAM17 | |
| SCHEMBL4046533 | 0.88 | MAPK1 (0.36) | GPR132CTSKACEACE2CTSB | |
| SCHEMBL4047615 | 0.87 | CTSB (0.38) | GPR132CTSKECE1ACECHRNA7 | |
| SCHEMBL4046868 | 0.85 | ITGB1 (0.37) | GPR132CTSKACE2CTSBCTSS | |
| SCHEMBL4042529 | 0.84 | BCL2 (0.38) | GPR132CTSKACECMKLR2CMKLR1 | |
| SCHEMBL4043883 | 0.83 | CTSK (0.42) | CTSKACEACE2CTSSITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |