Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL622126 | 0.98 | ALDH1A1 (0.33) | ALDH1A1POLBPNMTKDM4ESMN1; SMN2 | |
| SCHEMBL622443 | 0.88 | SLC6A9 (0.39) | ALDH1A1POLBKDM4EGAAAGBL2 | |
| SCHEMBL4821366 | 0.85 | KDM4E (0.36) | ALDH1A1POLBPNMTKDM4ESMN1; SMN2 | |
| SCHEMBL30590165 | 0.84 | ASIC3 (0.42) | ALDH1A1POLBPNMTSMN1; SMN2ASIC3 | |
| SCHEMBL714493 | 0.84 | ASIC3 (0.42) | ALDH1A1POLBPNMTSMN1; SMN2ASIC3 | |
| SCHEMBL30624154 | 0.84 | ASIC3 (0.42) | ALDH1A1ASIC3HTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL30331765 | 0.83 | ASIC3 (0.41) | ALDH1A1POLBSMN1; SMN2ASIC3HTR2C | |
| Hydrochloric Acid SCHEMBL1119948 | 0.83 | ASIC3 (0.41) | ALDH1A1POLBSMN1; SMN2ASIC3HTR2C | |
| Hydrochloric Acid SCHEMBL1119771 | 0.83 | ASIC3 (0.41) | ALDH1A1POLBSMN1; SMN2ASIC3HTR2C | |
| Hydrochloric Acid SCHEMBL1119945 | 0.83 | ASIC3 (0.41) | ALDH1A1POLBSMN1; SMN2ASIC3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 2013-03-07 | — | — | US | disclosed |
| US-8188139-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188139-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188139-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | PFLEGER CHRISTOPHE (FR) | 2012-02-16 | — | — | US | disclosed |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | PFLEGER CHRISTOPHE (FR) | 2012-02-16 | — | — | US | disclosed |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | PFLEGER CHRISTOPHE (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2225202-B1 | Preparation of dihydropyrrol derivatives as intermediates | HOFFMANN LA ROCHE (CH) | 2011-12-28 | — | — | EP | disclosed |
| US-7557114-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-7557114-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2009-07-07 | — | — | US | disclosed |
| WO-2009068463-A2 | PROCESS FOR THE PREPARATION OF ISOINDOLE DERIVATIVES AS WELL AS A PROCESS FOR THE PREPARATION OF THEIR INTERMEDIATES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
| CN-101119968-A | Heterocyclically substituted phenyl methanone derivatives as glycine transporter 1 inhibitors | HOFFMANN LA ROCHE (CH) | 2008-02-06 | — | — | CN | disclosed |
| EP-1848694-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F. Hoffmann-Roche AG (CH) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006082001-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| WO-2006082001-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| US-20060178381-A1 | Heterocyclic-substituted phenyl methanones | HOFFMANN-LA ROCHE INC. | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | DHPS, QDPR, SDHA | ALDH1A1 202/4885POLB 1613/4885PNMT 1841/4885 |
| US-20060178381-A1 | Heterocyclic-substituted phenyl methanones | CYP2B6, CYP2D6, CYP1A2 | ALDH1A1 52/4885POLB 2025/4885PNMT 1672/4885 |
| US-20120041205-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | DHPS, QDPR, SDHA | ALDH1A1 202/4885POLB 1613/4885PNMT 1841/4885 |
| US-20130060038-A1 | PREPARATION OF DIHYDROPYRROL DERIVATIVES AS INTERMEDIATES | DHPS, QDPR, SDHA | ALDH1A1 202/4885POLB 1613/4885PNMT 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.