Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | PLD2 | O14939 | 1/20 | 0.33 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213622 | 0.91 | LMNA (0.38) | LMNAALDH1A1HSD17B10SMYD3ELOVL6 | |
| SCHEMBL6212436 | 0.91 | LMNA (0.38) | LMNAALDH1A1HSD17B10SMYD3ELOVL6 | |
| SCHEMBL6211558 | 0.91 | LMNA (0.38) | LMNAALDH1A1PKMRXFP1RECQL | |
| SCHEMBL6212884 | 0.90 | LMNA (0.37) | LMNAALDH1A1PKMRXFP1L3MBTL1 | |
| SCHEMBL6208961 | 0.90 | CTSK (0.38) | LMNAALDH1A1HSD17B10KMT2AITGB3 | |
| SCHEMBL6209651 | 0.89 | LMNA (0.42) | LMNAELOVL6POLBKMT2A | |
| SCHEMBL6213162 | 0.89 | CTSK (0.42) | LMNAALDH1A1PKMRXFP1HSD17B10 | |
| SCHEMBL6211403 | 0.89 | NAMPT (0.37) | LMNAHSD17B10SMYD3ELOVL6 | |
| SCHEMBL6211427 | 0.89 | ALDH1A1 (0.36) | LMNAALDH1A1PKMRECQLHSD17B10 | |
| SCHEMBL6211220 | 0.88 | CHRM4 (0.38) | LMNAALDH1A1RECQLHSD17B10ELOVL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |