Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211364 | 0.92 | DPP4 (0.45) | RAB9ALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6209824 | 0.90 | DPP4 (0.47) | RAB9AMAPTLMNAALDH1A1GAA | |
| SCHEMBL6212587 | 0.90 | NAMPT (0.42) | CTSKLMNAALDH1A1NAMPTDPP4 | |
| SCHEMBL6211394 | 0.90 | LMNA (0.40) | RAB9ALMNAALDH1A1NAMPTDPP4 | |
| SCHEMBL5941964 | 0.89 | PKM (0.38) | LMNAALDH1A1NAMPTDPP4 | |
| SCHEMBL6258369 | 0.88 | LMNA (0.44) | LMNAALDH1A1HTTSMN1; SMN2NAMPT | |
| SCHEMBL6259546 | 0.87 | ALDH1A1 (0.46) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6209890 | 0.86 | DPP4 (0.37) | LMNAALDH1A1NAMPTDPP4SMYD3 | |
| SCHEMBL6211755 | 0.81 | DPP4 (0.45) | LMNAALDH1A1NAMPTDPP4SMYD3 | |
| SCHEMBL6210118 | 0.81 | DPP4 (0.44) | LMNAALDH1A1SMN1; SMN2NAMPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |