Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216870 | 0.89 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL11357352 | 0.84 | RAB9A (0.52) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL6214687 | 0.83 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| Hydrochloric Acid SCHEMBL11360651 | 0.83 | RAB9A (0.51) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL6215143 | 0.81 | ENPP2 (0.48) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL6491197 | 0.77 | ENPP2 (0.60) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL6215564 | 0.75 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL6216539 | 0.75 | KDM4E (0.43) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL2825625 | 0.75 | GAA (0.50) | ADRA2AADRA2BADRA2CADRA1AGAA | |
| SCHEMBL9203119 | 0.74 | PABPC1 (0.43) | ADRA2AADRA2BADRA2CADRA1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1256583-B1 | Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-10 | — | — | EP | disclosed |
| US-6747032-B2 | DOUBLE ALPHA 2/5-HT 2C ANTAGONISTS USED TO TREAT DEPRESSION, IMPULSIVE BEHAVIOUR DISORDERS, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, COGNITIVE DISORDERS AND DISORDERS INVOLVING SEXUAL FUNCTION, SLEEP AND EATING | LES LABORATOIRES SERVIER (FR) | 2004-06-08 | — | — | US | disclosed |
| US-20030087916-A1 | Pyrimidin-4-one compounds | LES LABORATOIRES SERVIER (FR) | 2003-05-08 | — | — | US | disclosed |
| EP-1256583-A1 | Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087916-A1 | Pyrimidin-4-one compounds | HTR2C, HTR1A, HTR4 | ADRA2A 34/4885ADRA2B 47/4885ADRA2C 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.