Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842188 | 0.91 | LTA4H (0.51) | TBK1LTA4HACHEALDH1A1IKBKE | |
| Trifluoroacetic Acid SCHEMBL4842767 | 0.87 | LTA4H (0.46) | TBK1LTA4HACHEALDH1A1CHEK2 | |
| SCHEMBL4844677 | 0.83 | KDM4E (0.47) | TBK1ALDH1A1IKBKECHEK2MEN1 | |
| Trifluoroacetic Acid SCHEMBL4844409 | 0.81 | ALDH1A1 (0.46) | TBK1ALDH1A1CHEK2MEN1KMT2A | |
| SCHEMBL6218463 | 0.79 | LTA4H (0.34) | TBK1LTA4HACHEALDH1A1IKBKE | |
| SCHEMBL4838238 | 0.79 | ABCB1 (0.45) | ALDH1A1 | |
| SCHEMBL5260412 | 0.78 | CHEK2 (0.41) | TBK1ALDH1A1CHEK2 | |
| SCHEMBL4844406 | 0.78 | ACHE (0.61) | TBK1LTA4HACHEIKBKECHEK2 | |
| SCHEMBL4834728 | 0.78 | CHEK2 (0.40) | TBK1ACHEALDH1A1CHEK2 | |
| SCHEMBL4840409 | 0.78 | ACHE (0.48) | TBK1LTA4HACHEIKBKECHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-A1 | USE OF AND SOME NOVEL IMIDAZOPYRIDINES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016611-A1 | USE OF AND SOME NOVEL IMIDAZOPYRIDINES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |