Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | SLC2A1 | P11166 | 11/20 | 0.61 |
| ▸ | SLC2A3 | P11169 | 11/20 | 0.61 |
| ▸ | SLC2A2 | P11168 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6205326 | 0.99 | GSK3B (0.61) | GSK3BMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL8344398 | 0.83 | LMNA (0.67) | GSK3BMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL838296 | 0.82 | SLC2A1 (0.66) | GSK3BMAPTKDM4ELMNASLC2A1 | |
| SCHEMBL6205196 | 0.81 | SLC2A1 (0.65) | GSK3BMAPTKDM4ELMNASLC2A1 | |
| SCHEMBL838951 | 0.81 | SLC2A1 (0.65) | GSK3BMAPTKDM4ELMNASLC2A1 | |
| SCHEMBL8344599 | 0.78 | SLC2A1 (0.58) | GSK3BMAPTKDM4ELMNASLC2A1 | |
| SCHEMBL8339901 | 0.78 | GSK3B (1.00) | GSK3B | |
| SCHEMBL8342553 | 0.78 | GSK3B (0.75) | GSK3B | |
| SCHEMBL6364028 | 0.77 | KDM4E (1.00) | MAPTKDM4ELMNAALDH1A1GAA | |
| SCHEMBL6206370 | 0.77 | KDM4E (0.73) | GSK3BMAPTKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |