Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 17/20 | 0.66 |
| ▸ | SLC2A3 | P11169 | 17/20 | 0.66 |
| ▸ | SLC2A2 | P11168 | 11/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838951 | 0.85 | SLC2A1 (0.65) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL6205196 | 0.85 | SLC2A1 (0.65) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL6224888 | 0.82 | GSK3B (0.62) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| Hydrochloric Acid SCHEMBL6205326 | 0.81 | GSK3B (0.61) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL8344599 | 0.80 | SLC2A1 (0.58) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL839270 | 0.78 | GCK (0.46) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL15105528 | 0.77 | CYP17A1 (0.62) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL839071 | 0.73 | ALDH1A1 (0.52) | SLC2A1SLC2A3SLC2A2MAPTKDM4E | |
| SCHEMBL15105690 | 0.73 | CYP17A1 (0.57) | SLC2A1SLC2A3SLC2A2GSK3BMAPT | |
| SCHEMBL8339901 | 0.72 | GSK3B (1.00) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | GCK, GCKR, GPR119 | SLC2A1 14/4885SLC2A3 17/4885SLC2A2 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.