Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6226643 | 0.88 | HTR3E (0.42) | HRH4MTNR1AHTR1AHTR3EHTR3B | |
| SCHEMBL6696172 | 0.83 | HTR6 (0.49) | HTR1AHTR7 | |
| SCHEMBL6700106 | 0.79 | KMT2A (0.46) | HRH4HTR1AHTR3EHTR3BHTR2C | |
| SCHEMBL6705597 | 0.77 | MTNR1A (0.39) | P2RX7MTNR1AALDH1A1 | |
| SCHEMBL6700145 | 0.77 | HTR1A (0.40) | HTR1AHTR7HTR3EHTR3BHTR2C | |
| SCHEMBL6693288 | 0.76 | HTR7 (0.48) | HTR1AHTR7HTR2C | |
| SCHEMBL6226610 | 0.75 | HTR1A (0.46) | HTR1AHTR7HTR2CCHKA | |
| SCHEMBL114576 | 0.75 | CXCR3 (0.51) | CXCR3ALDH1A1 | |
| SCHEMBL6248861 | 0.74 | CYP11B1 (0.56) | — | |
| SCHEMBL3739598 | 0.74 | CXCR3 (0.58) | CXCR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | PFIZER INC. | 2004-11-18 | — | — | US | claimed |
| EP-1592772-A2 | 5HT7 ANTAGONISTS AND INVERSE AGONISTS | Pfizer Products Incorporated (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | PFIZER INC. | 2004-11-18 | — | — | US | disclosed |
| WO-2004067703-A2 | 5HT7 ANTAGONISTS AND INVERSE AGONISTS | PFIZER PRODUCTS INC. (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | HTR7, HTR1A, HTR1B | HRH4 236/4885CXCR3 1321/4885P2RX7 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.