Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.34 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.34 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722636 | 0.84 | PCSK9 (0.45) | ALDH1A1PCSK9MEN1KMT2AHPGD | |
| SCHEMBL5953336 | 0.82 | LPL (0.50) | ALDH1A1PCSK9MEN1KMT2AHTT | |
| SCHEMBL29116247 | 0.75 | NPC1 (0.44) | ALDH1A1PCSK9KMT2ALMNAKCNH2 | |
| Ether SCHEMBL8472514 | 0.72 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AHTTLMNA | |
| Toluene SCHEMBL9334989 | 0.71 | TSHR (0.39) | ALDH1A1PCSK9MEN1KMT2ALMNA | |
| Phenylboronic Acid SCHEMBL9951962 | 0.71 | CA2 (0.59) | ALDH1A1HPGDSMN1; SMN2TDP1CA2 | |
| SCHEMBL1275435 | 0.70 | PCSK9 (0.47) | ALDH1A1PCSK9MEN1KMT2AHTT | |
| Benzene SCHEMBL29168416 | 0.70 | ALDH1A1 (0.87) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL1129435 | 0.69 | TRPV6 (0.44) | ALDH1A1PCSK9MEN1KMT2AHPGD | |
| SCHEMBL2474216 | 0.68 | ACHE (0.43) | PCSK9HTTLMNAALOX12SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |