SCHEMBL6230258

SCHEMBL6230258

O=C(NOc1ccccc1)Nc1nc(NC(=O)NOc2ccccc2)nc(NC(=O)NOc2ccccc2)n1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 5/20 0.56
CDK5R1 Q15078 5/20 0.56
CCNA2 P20248 2/20 0.56
CDK2 P24941 2/20 0.56
CCNA1 P78396 2/20 0.56
GAA P10253 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
METAP2 P50579 3/20 0.39
METAP1 P53582 2/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
TP53 P04637 2/20 0.38
ADORA1 P30542 2/20 0.38
EPHX1 P07099 1/20 0.38
TSHR P16473 1/20 0.38
EPHX2 P34913 1/20 0.38
CDK9 P50750 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10773023 0.81 TSHR (0.61) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL13922742 0.75 SMN1; SMN2 (0.47) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL9453149 0.75 MEN1 (0.47) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL27576014 0.74 TAAR1 (0.66) CDK5CDK5R1TP53EPHX1TSHR
SCHEMBL3590919 0.73 METAP2 (0.46) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL7244914 0.73 ALDH1A1 (0.56) CDK5CDK2GAARAB9ATP53
SCHEMBL1894738 0.73 CDK2 (0.64) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL3646258 0.71 MEN1 (0.52) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL10728474 0.71 METAP2 (0.45) CDK5CDK5R1CCNA2CDK2CCNA1
SCHEMBL28899751 0.70 CA2 (0.74) CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1089986-B1 POLY-TRISARYL-1,3,5-TRIAZINE CARBAMATE ULTRAVIOLET LIGHT ABSORBERS CIBA SC HOLDING AG (CH) 2005-03-30 EP disclosed
US-6306939-B1 PHOTOSTABILITY, PHOTOGRAPHIC MATERIALS CIBA SPECIALTY CHEMICALS CORPORATION 2001-10-23 US disclosed
EP-1089986-A1 POLY-TRISARYL-1,3,5-TRIAZINE CARBAMATE ULTRAVIOLET LIGHT ABSORBERS Ciba SC Holding AG (CH) 2001-04-11 EP disclosed
WO-1999067227-A1 POLY-TRISARYL-1,3,5-TRIAZINE CARBAMATE ULTRAVIOLET LIGHT ABSORBERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-12-29 WO disclosed