Sugi Predict

Sugi Predict / Compounds / Sampangine

Sampangine

Sampangine

SCHEMBL6230423

O=C1c2ccccc2-c2nccc3ccnc1c23

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 3/20 0.74
▸ ALDH1A1 P00352 2/20 0.62
▸ PTPRC P08575 2/20 0.55
▸ CTSL P07711 1/20 0.55
▸ CTSS P25774 1/20 0.55
▸ PTPN13 Q12923 1/20 0.55
▸ NPC1 O15118 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ AHR P35869 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ TOP2A P11388 1/20 0.45
▸ TDP2 O95551 1/20 0.45
▸ NSD2 O96028 1/20 0.45
▸ ABL1 P00519 1/20 0.45
▸ PLCG1 P19174 1/20 0.45
▸ CES1 P23141 1/20 0.45
▸ PAX8 Q06710 1/20 0.45
▸ RIN1 Q13671 1/20 0.45
▸ MEN1 O00255 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eupolauridine SCHEMBL3125284 0.88 MAOA (0.66) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL25380689 0.85 MAOA (0.75) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL1969983 0.85 MAOA (1.00) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL29869412 0.85 MAOA (0.75) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL30416588 0.84 MAOA (0.97) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL28075835 0.84 MAOA (0.97) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL29409625 0.83 MEN1 (0.59) MAOAPTPRCCTSLCTSSPTPN13
SCHEMBL6414025 0.83 TDP2 (0.64) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL20256663 0.82 MAOA (0.56) MAOAALDH1A1PTPRCCTSLCTSS
SCHEMBL20256433 0.82 MAOA (0.53) MAOAALDH1A1PTPRCCTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106905317-B 4- replaces Sampangine alcaloid-derivatives and its synthetic method and application 广西师范大学 2019-03-22 — — CN claimed
CN-106905317-A 4 substitution Sampangine alcaloid-derivatives and its synthetic method and application 广西师范大学 2017-06-30 — — CN claimed
US-20170112824-A1 COMBINATION THERAPIES FOR THE TREATMENT OF FUNGAL INFECTIONS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-04-27 — — US claimed
US-6844353-B2 Fungicidal properties of sampangine and its analogs to agriculturally important fungal plant pathogens THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 2005-01-18 — — US claimed
WO-2004086861-A2 FUNGICIDAL PROPERTIES OF SAMPANGINE AND ITS ANALOGS TO AGRICULTURALLY IMPORTANT FUNGAL PLANT PATHOGENS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 2004-10-14 — — WO claimed
US-20040192721-A1 Fungicidal properties of sampangine and its analogs to agriculturally important fungal plant pathogens UNIVERSITY OF MISSISSIPPI, THE 2004-09-30 — — US claimed
EP-0588796-B1 SAMPANGINE DERIVATIVES USEFUL AS ANTIFUNGAL AND ANTIMYCOBACTERIAL AGENTS UNIV MISSISSIPPI (US) 2001-04-04 — — EP claimed
EP-0588796-A4 NEW COMPOUNDS AND COMPOSITIONS USEFUL AS ANTIFUNGAL AND ANTIMYCOBACTERIAL AGENTS UNIV MISSISSIPPI RES INST (US) 1994-09-14 — — EP claimed
EP-0588796-A1 NEW COMPOUNDS AND COMPOSITIONS USEFUL AS ANTIFUNGAL AND ANTIMYCOBACTERIAL AGENTS THE UNIVERSITY OF MISSISSIPPI (US) 1994-03-30 — — EP claimed
EP-0556319-A4 — — 1994-01-19 — — EP claimed
EP-0556319-A1 SAMPANGINE AND DERIVATIVES USEFUL AS ANTIFUNGAL AGENTS THE UNIVERSITY OF MISSISSIPPI (US) 1993-08-25 — — EP claimed
US-5227383-A Sampangine analogs THE UNIVERSITY OF MISSISSIPPI (US) 1993-07-13 — — US claimed
WO-1992022297-A1 NEW COMPOUNDS AND COMPOSITIONS USEFUL AS ANTIFUNGAL AND ANTIMYCOBACTERIAL AGENTS THE UNIVERSITY OF MISSISSIPPI (US) 1992-12-23 — — WO claimed
US-5156847-A Aporphinoid alkaloid in nonaqueous solvent Lewis, Walter H. (US) 1992-10-20 — — US claimed
US-5128344-A SAMPANGINE AND DERIVATIVES USEFUL AS AN ANTIFUNGAL AGENT UNIVERSITY OF MISSISSIPPI (US) 1992-07-07 — — US claimed
WO-1992007565-A1 SAMPANGINE AND DERIVATIVES USEFUL AS ANTIFUNGAL AGENTS THE UNIVERSITY OF MISSISSIPPI (US) 1992-05-14 — — WO claimed
CN-122094976-A Multichain chimeric polypeptides and uses thereof — 2026-05-26 — — CN disclosed
CN-122094703-A Multichain chimeric polypeptides and their use in the treatment of advanced solid tumors — 2026-05-26 — — CN disclosed
WO-1992007565-A1 SAMPANGINE AND DERIVATIVES USEFUL AS ANTIFUNGAL AGENTS THE UNIVERSITY OF MISSISSIPPI (US) 1992-05-14 — — WO disclosed
WO-1992007565-A1 SAMPANGINE AND DERIVATIVES USEFUL AS ANTIFUNGAL AGENTS THE UNIVERSITY OF MISSISSIPPI (US) 1992-05-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040192721-A1 Fungicidal properties of sampangine and its analogs to agriculturally important fungal plant pathogens SAMSN1, SAMHD1, SPIN4 MAOA 873/4885ALDH1A1 1466/4885PTPRC 3776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.