SCHEMBL6231645

SCHEMBL6231645

COc1ccc2c(c1)Sc1cc(N(C)C)ccc1N2C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 6/20 1.00
LMNA P02545 2/20 0.48
MAPK1 P28482 4/20 0.45
TP53 P04637 2/20 0.45
KDM4E B2RXH2 2/20 0.45
MEN1 O00255 5/20 0.45
KMT2A Q03164 5/20 0.45
L3MBTL1 Q9Y468 3/20 0.45
TDP1 Q9NUW8 2/20 0.45
PKM P14618 3/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 2/20 0.43
NPC1 O15118 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
CASP1 P29466 1/20 0.43
BRCA1 P38398 1/20 0.43
RAB9A P51151 1/20 0.43
CASP7 P55210 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3419052 0.87 SNCA (0.76) SNCALMNAMAPK1KDM4EMEN1
SCHEMBL7389154 0.87 SNCA (0.81) SNCALMNAMAPK1TP53KDM4E
SCHEMBL21752026 0.82 SNCA (0.69) SNCALMNAMAPK1TP53KDM4E
SCHEMBL7123151 0.80 SNCA (0.69) SNCALMNAMAPK1TP53KDM4E
SCHEMBL9560319 0.80 SNCA (0.66) SNCALMNAMAPK1TP53KDM4E
SCHEMBL25494058 0.76 SNCA (0.61) SNCAMAPK1MEN1KMT2AL3MBTL1
SCHEMBL25609760 0.76 SNCA (0.61) SNCALMNAMAPK1MEN1KMT2A
SCHEMBL2760350 0.76 SNCA (0.64) SNCALMNAMAPK1TP53KDM4E
SCHEMBL9009137 0.75 MEN1 (0.72) SNCAMAPK1KDM4EMEN1KMT2A
SCHEMBL9639556 0.74 SNCA (0.61) SNCALMNAMAPK1TP53KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3594207-B1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORP (US) 2021-06-30 EP disclosed
US-10971718-B2 Electrochemical energy storage devices GENTEX CORPORATION (US) 2021-04-06 US disclosed
US-20200050070-A1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORPORATION 2020-02-13 US disclosed
US-10481456-B2 Electrochemical energy storage devices GENTEX CORPORATION (US) 2019-11-19 US disclosed
EP-3164390-B1 ELECTROCHROMIC DEVICES AND COMPOUNDS THEREFOR GENTEX CORP (US) 2019-09-18 EP disclosed
US-20180157139-A1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORPORATION 2018-06-07 US disclosed
US-20180157139-A1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORPORATION 2018-06-07 US disclosed
US-9964828-B2 Electrochemical energy storage devices GENTEX CORPORATION (US) 2018-05-08 US disclosed
US-9964828-B2 Electrochemical energy storage devices GENTEX CORPORATION (US) 2018-05-08 US disclosed
WO-2015183821-A1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORPORATION (US) 2015-12-03 WO disclosed
US-20150346573-A1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORPORATION 2015-12-03 US disclosed
US-20150346573-A1 ELECTROCHEMICAL ENERGY STORAGE DEVICES GENTEX CORPORATION 2015-12-03 US disclosed
US-20130315825-A1 TRICYCLIC HETEROAROMATIC COMPOUNDS AS ALPHA-SYNUCLEIN LIGANDS WASHINGTON UNIVERSITY (US) 2013-11-28 US disclosed
EP-1060224-B1 NEAR INFRARED-ABSORBING ELECTROCHROMIC COMPOUNDS AND DEVICES COMPRISING SAME GENTEX CORP (US) 2005-05-25 EP disclosed
US-6193912-B1 SOLUTION PHASE ANODIC COMPOUND; ATTENUATION OF SUNLIGHT TRANSMITTANCE THROUGH BUILDING WINDOWS GENTEX CORPORATION 2001-02-27 US disclosed
EP-1060224-A1 NEAR INFRARED-ABSORBING ELECTROCHROMIC COMPOUNDS AND DEVICES COMPRISING SAME GENTEX CORPORATION (US) 2000-12-20 EP disclosed
WO-1999045081-A1 NEAR INFRARED-ABSORBING ELECTROCHROMIC COMPOUNDS AND DEVICES COMPRISING SAME GENTEX CORPORATION (US) 1999-09-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130315825-A1 TRICYCLIC HETEROAROMATIC COMPOUNDS AS ALPHA-SYNUCLEIN LIGANDS SNCA, PARK7, HTT SNCA 1/4885LMNA 2602/4885MAPK1 3800/4885
US-10971718-B2 Electrochemical energy storage devices PC, PANK2, MCU SNCA 2669/4885LMNA 1061/4885MAPK1 2932/4885
US-10481456-B2 Electrochemical energy storage devices PC, PANK2, VDAC2 SNCA 1688/4885LMNA 1699/4885MAPK1 3548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.