Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL28535952 | 0.95 | TSHR (0.53) | TSHRCYP2D6POLBCETPFDFT1 | |
| SCHEMBL28538163 | 0.95 | TSHR (0.53) | TSHRCYP2D6POLBCETPFDFT1 | |
| SCHEMBL6229513 | 0.95 | TSHR (0.53) | TSHRCYP2D6POLBCETPFDFT1 | |
| Zinc Ion SCHEMBL28535948 | 0.83 | TSHR (0.50) | TSHRPOLBFDFT1SMN1; SMN2 | |
| SCHEMBL28529985 | 0.83 | TSHR (0.50) | TSHRPOLBFDFT1SMN1; SMN2 | |
| Zinc Ion SCHEMBL28530931 | 0.81 | TSHR (0.53) | TSHRCETPFDFT1ALDH1A1ALOX12 | |
| SCHEMBL28541500 | 0.81 | TSHR (0.53) | TSHRCETPFDFT1ALDH1A1ALOX12 | |
| Zinc Ion SCHEMBL28543480 | 0.79 | TSHR (0.52) | TSHRCETPFDFT1ALDH1A1ALOX12 | |
| SCHEMBL28530941 | 0.79 | TSHR (0.52) | TSHRCETPFDFT1ALDH1A1ALOX12 | |
| SCHEMBL6446401 | 0.77 | ALDH1A1 (0.61) | TSHRCYP2D6POLBALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214378-B1 | FLAME RETARDANT POLYCARBONATE COMPOSITION | BAYER AG (US) | 2005-04-06 | — | — | EP | claimed |
| EP-0182226-B1 | PROCESS FOR THE PREPARATION OF FLAME-RETARDANT TETRAFLUOROETHYLENE-POLYMERISATE CONTAINING POLYCARBONATE MOULDING COMPOSITIONS | BAYER AG (DE) | 1990-04-18 | — | — | EP | disclosed |
| EP-0138173-B1 | FIRE PROOFERS, THEIR PREPARATION AND THEIR USE IN FIRE-PROOF POLYCARBONATES | BAYER AG (DE) | 1987-12-23 | — | — | EP | disclosed |
| EP-0182226-A2 | Process for the preparation of flame-retardant tetrafluoroethylene-polymerisate containing polycarbonate moulding compositions | BAYER AG (DE) | 1986-05-28 | — | — | EP | disclosed |
| EP-0138173-A2 | Fire proofers, their preparation and their use in fire-proof polycarbonates | BAYER AG (DE) | 1985-04-24 | — | — | EP | disclosed |