SCHEMBL623309

SCHEMBL623309

CC(N)CCc1ccccc1I

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 4/20 0.61
SLC6A4 P31645 3/20 0.61
SLC6A3 Q01959 3/20 0.61
TAAR1 Q96RJ0 3/20 0.55
IDO1 P14902 2/20 0.44
MAOA P21397 4/20 0.38
SIGMAR1 Q99720 1/20 0.38
CYP2A6 P11509 1/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38
ADRB1 P08588 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
HTR1D P28221 1/20 0.36
HTR1B P28222 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR1E P28566 1/20 0.36
HTR7 P34969 1/20 0.36
HTR2B P41595 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30520633 1.00 SLC6A2 (0.61) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL4368919 0.83 TAAR1 (0.54) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL3243108 0.80 TAAR1 (0.50) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL1006209 0.79 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL15945059 0.78 SLC6A4 (0.63) SLC6A2SLC6A4SLC6A3TAAR1MAOA
SCHEMBL24182615 0.76 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL623391 0.76 SLC6A2 (0.61) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL30520716 0.76 SLC6A4 (0.61) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL30520623 0.76 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3TAAR1IDO1
SCHEMBL268859 0.76 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3TAAR1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250186369-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING, AMELIORATING, AND/OR PRVENTING COCAINE USE DISORDER UNIV DREXEL (US) 2025-06-12 US claimed
US-20240074993-A1 METHODS OF TREATING OR PREVENTING AN ATTENTION DISORDER, COGNITIVE DISORDER, AND/OR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER UNIV DREXEL (US) 2024-03-07 US claimed
WO-2023172497-A2 COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING, AMELIORATING, AND/OR PREVENTING COCAINE USE DISORDER DREXEL UNIVERSITY (US) 2023-09-14 WO claimed
US-20220233475-A1 NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE UNIV DREXEL (US) 2022-07-28 US claimed
US-10695302-B2 Treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder DREXEL UNIVERSITY (US) 2020-06-30 US claimed
EP-3062791-B1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER UNIV DREXEL (US) 2020-01-08 EP claimed
CN-109745313-A The D3 dopamine-receptor stimulant for treating dyskinesia in Parkinson's disease 德雷克塞尔大学 2019-05-14 CN claimed
US-20180092865-A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER DREXEL UNIVERSITY (US) 2018-04-05 US claimed
US-9861594-B2 Treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder DREXEL UNIVERSITY (US) 2018-01-09 US claimed
US-9675565-B2 D3 dopamine receptor agonists to treat dyskinesia in parkinson's disease DREXEL UNIVERSITY (US) 2017-06-13 US claimed
US-20160256417-A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER DREXEL UNIVERSITY (US) 2016-09-08 US claimed
EP-3062791-A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER Drexel University (US) 2016-09-07 EP claimed
US-9289400-B2 D3 dopamine receptor agonists to treat dyskinesia in parkinson's disease DREXEL UNIVERSITY (US) 2016-03-22 US claimed
WO-2015066019-A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER DREXEL UNIVERSITY (US) 2015-05-07 WO claimed
US-20140228380-A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease UNIVERSITY OF MEDICINE AND DENTISTRY NEW JERSEY MEDICAL SCHOOL (US) 2014-08-14 US claimed
US-20140228355-A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease UNIVERSITY OF MEDICINE AND DENTISTRY NEW JERSEY MEDICAL SCHOOL (US) 2014-08-14 US claimed
EP-2603215-A2 NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE Philadelphia Health and Education Corporation (US) 2013-06-19 EP claimed
WO-2012021629-A2 NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) 2012-02-16 WO claimed
US-20250186369-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING, AMELIORATING, AND/OR PRVENTING COCAINE USE DISORDER UNIV DREXEL (US) 2025-06-12 US disclosed
WO-2012021629-A2 NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) 2012-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10695302-B2 Treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder CHAT, ACHE, SLC18A3 SLC6A2 10/4885SLC6A4 23/4885SLC6A3 11/4885
US-20240074993-A1 METHODS OF TREATING OR PREVENTING AN ATTENTION DISORDER, COGNITIVE DISORDER, AND/OR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER CHAT, COMT, SLC6A2 SLC6A2 3/4885SLC6A4 15/4885SLC6A3 5/4885
US-20220233475-A1 NOVEL D3 DOPAMINE RECEPTOR AGONISTS TO TREAT DYSKINESIA IN PARKINSON'S DISEASE DRD3, PARK7, SLC6A3 SLC6A2 128/4885SLC6A4 235/4885SLC6A3 3/4885
US-20140228380-A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease DRD3, PARK7, SLC6A3 SLC6A2 128/4885SLC6A4 235/4885SLC6A3 3/4885
US-20180092865-A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER CHAT, BDNF, SLC18A3 SLC6A2 13/4885SLC6A4 26/4885SLC6A3 10/4885
US-20160256417-A1 NOVEL TREATMENTS FOR ATTENTION AND COGNITIVE DISORDERS, AND FOR DEMENTIA ASSOCIATED WITH A NEURODEGENERATIVE DISORDER CHAT, BDNF, SLC18A3 SLC6A2 13/4885SLC6A4 26/4885SLC6A3 10/4885
US-20250186369-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING, AMELIORATING, AND/OR PRVENTING COCAINE USE DISORDER CES2, CHAT, SLC18A2 SLC6A2 7/4885SLC6A4 33/4885SLC6A3 4/4885
US-20140228355-A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease DRD3, PARK7, SLC6A3 SLC6A2 128/4885SLC6A4 235/4885SLC6A3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.