SCHEMBL623310

SCHEMBL623310

COC(=O)CCCCC(=O)N[C@H](C(=O)NC(Cc1ccccc1)C(=O)CF)C(C)C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.47
HDAC1 Q13547 5/20 0.47
HDAC6 Q9UBN7 5/20 0.47
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
CTSG P08311 1/20 0.47
CMA1 P23946 1/20 0.47
CTSD P07339 2/20 0.45
REN P00797 4/20 0.43
ALDH1A1 P00352 1/20 0.43
THRB P10828 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL622809 0.99 HDAC1 (0.48) CASP1HDAC1HDAC6HDAC3HDAC4
SCHEMBL621465 0.84 CAPN1 (0.52) CASP1HDAC1HDAC6CTSD
SCHEMBL621676 0.82 CTSD (0.50) CTSDREN
SCHEMBL12473604 0.82 CASP3 (0.47) CASP1ALDH1A1THRBCYP2C9CYP2C19
SCHEMBL622823 0.81 CTSB (0.54) CTSD
SCHEMBL623185 0.81 CYP3A4 (0.54) CASP1HDAC1HDAC6CTSDALDH1A1
SCHEMBL623151 0.81 ALDH1A1 (0.45) CASP1CTSDALDH1A1THRBCYP2C9
SCHEMBL623892 0.81 CASP3 (0.46) CASP1ALDH1A1THRBCYP2C9CYP2C19
SCHEMBL622532 0.81 CAPN1 (0.55) CASP1CTSD
SCHEMBL622810 0.80 CTSB (0.53) CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012021788-A2 DIPEPTIDE CALPAIN INHIBITORS BANYAN BIOMARKERS (US) 2012-02-16 WO disclosed
WO-2012021788-A2 DIPEPTIDE CALPAIN INHIBITORS BANYAN BIOMARKERS (US) 2012-02-16 WO disclosed