Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | FEN1 | P39748 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234051 | 0.90 | ALOX5AP (0.43) | MPLCHUKTXNRD1NOX4ALOX5AP | |
| SCHEMBL8110983 | 0.84 | MPL (0.58) | MPLALOX5APFEN1BACE1EPHX2 | |
| SCHEMBL17141655 | 0.82 | MRGPRX4 (0.41) | KDM4EPIK3CAMEN1KMT2AHPGD | |
| SCHEMBL2901258 | 0.76 | LTA4H (0.53) | KDM4EMEN1KMT2AFBP1 | |
| SCHEMBL6240125 | 0.73 | HSD17B1 (0.44) | MPLALOX5APFEN1FBP1 | |
| SCHEMBL6234055 | 0.73 | ESR2 (0.43) | ALOX5APFEN1POLBMEN1KMT2A | |
| SCHEMBL6238840 | 0.73 | XDH (0.52) | KDM4EALDH1A1PIK3CA | |
| SCHEMBL29620904 | 0.71 | NPSR1 (0.44) | ALOX5APFEN1KDM4EALDH1A1KMT2A | |
| SCHEMBL6240121 | 0.71 | MPL (0.40) | MPLALOX5APFEN1CYP1A2CYP2C19 | |
| SCHEMBL21884348 | 0.70 | XDH (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |