Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901258 | 0.82 | LTA4H (0.53) | ADORA2AKDM1ATLR8KDM4EIKBKB | |
| SCHEMBL6238252 | 0.78 | LTA4H (0.37) | XDHADORA2AADORA1PIK3CAKDM4E | |
| SCHEMBL14564374 | 0.77 | ENPP3 (0.45) | ADORA2AADORA1RAB9ANPC1KMO | |
| SCHEMBL6256565 | 0.76 | CTSS (0.60) | XDHCTSSIDO1ADORA2AADORA1 | |
| SCHEMBL4539598 | 0.76 | RAB9A (0.54) | IDO1ADORA2AADORA1RAB9ANPC1 | |
| SCHEMBL6234051 | 0.74 | ALOX5AP (0.43) | PIK3CAKDM4EALDH1A1 | |
| SCHEMBL8110983 | 0.74 | MPL (0.58) | IDO1KDM1A | |
| SCHEMBL8119166 | 0.74 | LTA4H (0.54) | NOTUMADORA2AADORA1RAB9ANPC1 | |
| SCHEMBL1358158 | 0.73 | XDH (0.57) | XDHCTSSIDO1ADORA2AADORA1 | |
| SCHEMBL474410 | 0.73 | LTA4H (0.67) | XDHCTSSRAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |