Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234051 | 0.78 | ALOX5AP (0.43) | POLBALOX5APFEN1FBP1 | |
| SCHEMBL6240121 | 0.77 | MPL (0.40) | TSHRALOX5APFEN1FBP1VCP | |
| SCHEMBL6233703 | 0.73 | MPL (0.40) | POLBALOX5APFEN1FBP1MEN1 | |
| SCHEMBL6240125 | 0.73 | HSD17B1 (0.44) | ESR2HSD17B1HSD17B2ALOX5APFEN1 | |
| SCHEMBL5792355 | 0.73 | GLA (0.54) | ESR2HSD17B1HSD17B2GLAPOLB | |
| SCHEMBL31256038 | 0.73 | GLA (0.54) | ESR2HSD17B1HSD17B2GLAPOLB | |
| SCHEMBL3395686 | 0.72 | HSD17B1 (0.40) | ESR2HSD17B1HSD17B2GLAPOLB | |
| SCHEMBL6239462 | 0.71 | NOTUM (0.44) | ALOX5APFEN1SCN9A | |
| SCHEMBL8110983 | 0.69 | MPL (0.58) | ALOX5APFEN1LTA4H | |
| SCHEMBL7933583 | 0.69 | LTA4H (0.56) | ESR2HSD17B1HSD17B2POLBAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |