Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.43 |
| ▸ | FEN1 | P39748 | 4/20 | 0.43 |
| ▸ | MPL | P40238 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233703 | 0.90 | MPL (0.40) | ALOX5APFEN1MPLALDH1A1KDM4E | |
| SCHEMBL8110983 | 0.82 | MPL (0.58) | ALOX5APFEN1MPLBACE1EPHX2 | |
| SCHEMBL6234055 | 0.78 | ESR2 (0.43) | ALOX5APFEN1FBP1POLB | |
| SCHEMBL2901258 | 0.77 | LTA4H (0.53) | KDM4EFBP1 | |
| SCHEMBL6238840 | 0.74 | XDH (0.52) | ALDH1A1KDM4EPIK3CA | |
| SCHEMBL29620904 | 0.72 | NPSR1 (0.44) | ALOX5APFEN1ALDH1A1KDM4EFBP1 | |
| SCHEMBL6240125 | 0.72 | HSD17B1 (0.44) | ALOX5APFEN1MPLFBP1 | |
| SCHEMBL6240121 | 0.72 | MPL (0.40) | ALOX5APFEN1MPLBACE1FBP1 | |
| SCHEMBL17141655 | 0.72 | MRGPRX4 (0.41) | KDM4EPIK3CA | |
| SCHEMBL6238252 | 0.68 | LTA4H (0.37) | ALOX5APFEN1ALDH1A1KDM4EBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |