Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557262 | 0.92 | KIF11 (0.35) | KIF11APOBEC3GSLC22A12KCNA5CYP1A2 | |
| SCHEMBL864206 | 0.80 | APOBEC3G (0.55) | KIF11APOBEC3G | |
| SCHEMBL6238584 | 0.70 | ALDH1A1 (0.44) | KIF11APOBEC3GCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1769946 | 0.67 | CYP11B2 (0.53) | SLC22A12KCNA5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3078934 | 0.67 | SLC22A12 (0.43) | SLC22A12 | |
| SCHEMBL7557430 | 0.66 | KCNA5 (0.42) | KIF11KCNA5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29900474 | 0.65 | AOC1 (0.43) | GAA | |
| SCHEMBL6249306 | 0.65 | AOC1 (0.43) | GAA | |
| SCHEMBL5109030 | 0.65 | CYP11B1 (0.47) | — | |
| SCHEMBL5110350 | 0.65 | CYP11B1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222194-B1 | 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTICS AND PRODRUGS THEREOF | TRINE PHARMACEUTICALS INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6723716-B1 | BACTERICIDE FOR STAPHYLOCOCCUS | ESSENTIAL THERAPEUTICS, INC. | 2004-04-20 | — | — | US | disclosed |
| EP-1222194-A1 | 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTICS AND PRODRUGS THEREOF | Essential Therapeutics, Inc. (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001021623-A1 | 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTICS AND PRODRUGS THEREOF | ESSENTIAL THERAPEUTICS, INC. (US) | 2001-03-29 | — | — | WO | disclosed |
| US-6030965-A | WIDE SPECTRAM ANTIBIOTICS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025352-A | Cephalosporin antibiotics | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-02-15 | — | — | US | disclosed |