Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | MPL | P40238 | 3/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3C2B | O00750 | 4/20 | 0.33 |
| ▸ | MTOR | P42345 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240121 | 0.82 | MPL (0.40) | NOTUMMPLALOX5APFEN1SCN9A | |
| SCHEMBL14910950 | 0.71 | NOTUM (0.50) | NOTUMMPLHSD11B1BACE1 | |
| SCHEMBL6234055 | 0.71 | ESR2 (0.43) | ALOX5APFEN1SCN9A | |
| SCHEMBL6236903 | 0.70 | AR (0.44) | ALOX5APFEN1 | |
| SCHEMBL20242216 | 0.69 | MPL (0.51) | NOTUMMPLALOX5APFEN1TLR8 | |
| SCHEMBL4835226 | 0.68 | ENPP1 (0.50) | TLR8 | |
| SCHEMBL26375542 | 0.67 | ENPP3 (0.44) | NOTUMHSD11B1SCN9APTPN1 | |
| SCHEMBL16481960 | 0.67 | PDK2 (0.51) | NOTUMHSD11B1 | |
| SCHEMBL6238840 | 0.67 | XDH (0.52) | NOTUMTLR8PIK3CDPIK3CGPIK3CA | |
| SCHEMBL6630838 | 0.67 | TAS2R14 (0.46) | NOTUMMPLHSD11B1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |