Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235628 | 0.94 | KDM4C (0.48) | GPBAR1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL6989757 | 0.82 | MAPT (0.47) | KMT2AALDH1A1MAPTKDM4EKDM4A | |
| SCHEMBL6989518 | 0.82 | ALDH1A1 (0.46) | KMT2AALDH1A1MAPTKDM4AKDM5A | |
| SCHEMBL6987326 | 0.82 | ALDH1A1 (0.43) | KMT2AALDH1A1MAPTKDM4EKDM6B | |
| SCHEMBL5210605 | 0.81 | CFTR (0.55) | KMT2AALDH1A1MAPTKDM4EKDM6B | |
| SCHEMBL6985789 | 0.80 | HDAC1 (0.51) | ALDH1A1MAPTKDM4EKDM4AKDM4C | |
| SCHEMBL6988723 | 0.79 | SMN1; SMN2 (0.47) | KMT2AALDH1A1MAPTKDM4EKDM4A | |
| SCHEMBL6985787 | 0.75 | KDM4A (0.50) | ALDH1A1MAPTKDM4EKDM6BTET3 | |
| SCHEMBL5210601 | 0.74 | KDM4E (0.56) | KMT2AALDH1A1MAPTKDM4EKDM6B | |
| SCHEMBL5214358 | 0.74 | PPARG (0.55) | KMT2AALDH1A1MAPTHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530467-A2 | COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004006912-A2 | COMBINATION OF AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |