Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987326 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6989518 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1MAPTTP53MEN1 | |
| SCHEMBL6989757 | 0.81 | MAPT (0.47) | SMN1; SMN2ALDH1A1KDM4EMAPTTP53 | |
| SCHEMBL6235626 | 0.79 | GPBAR1 (0.47) | ALDH1A1KDM4EMAPTKMT2AKDM4A | |
| SCHEMBL6985789 | 0.79 | HDAC1 (0.51) | SMN1; SMN2ALDH1A1KDM4EMAPTKDM4A | |
| SCHEMBL5210605 | 0.77 | CFTR (0.55) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL11900421 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1KDM4EMAPTTP53 | |
| SCHEMBL6990533 | 0.77 | SLC2A1 (0.53) | ALDH1A1MAPTMEN1KMT2ATSHR | |
| SCHEMBL6990355 | 0.77 | SLC2A1 (0.61) | SMN1; SMN2POLB | |
| SCHEMBL6989554 | 0.74 | HRH1 (0.41) | MAPTTSHRKDM4CRAF1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362033-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-11-19 | — | — | EP | claimed |
| WO-2002064568-A1 | PYRIDINE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |