Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methyprylon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyprylon SCHEMBL1326559 | 1.00 | LMNA (0.32) | LMNACYP19A1 | |
| Methyprylon SCHEMBL7683591 | 0.89 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL155838 | 0.87 | LMNA (0.40) | LMNACYP19A1 | |
| Methyprylon SCHEMBL155839 | 0.87 | LMNA (0.40) | LMNACYP19A1 | |
| Methyprylon SCHEMBL8663851 | 0.84 | LMNA (0.33) | LMNACYP19A1 | |
| Methyprylon SCHEMBL10792726 | 0.84 | LMNA (0.38) | LMNACYP19A1 | |
| Methyprylon SCHEMBL9014931 | 0.83 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL6695974 | 0.83 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL8665659 | 0.69 | — | — | |
| Fumaric Acid SCHEMBL29291370 | 0.60 | TSHR (0.64) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011514671-A | — | — | 2011-05-06 | — | — | JP | claimed |
| US-20110046268-A1 | Self-Filleting Die Attach Paste | WANG MINGHAI | 2011-02-24 | — | — | US | claimed |
| EP-2250227-A1 | SELF-FILLETING DIE ATTACH PASTE | Henkel AG & Co. KGaA (DE) | 2010-11-17 | — | — | EP | claimed |
| WO-2009105911-A1 | SELF-FILLETING DIE ATTACH PASTE | NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING COPORATION (US) | 2009-09-03 | — | — | WO | claimed |
| US-11891537-B2 | Triphenylphosphine-containing coatings with enhanced adhesion to unprimed surfaces | SHEBOYGAN PAINT COMPANY (US) | 2024-02-06 | — | — | US | disclosed |
| US-20220325110-A1 | TRIPHENYLPHOSPHINE-CONTAINING COATINGS WITH ENHANCED ADHESION TO UNPRIMED SURFACES | SHEBOYGAN PAINT COMPANY | 2022-10-13 | — | — | US | disclosed |
| WO-2022212457-A1 | TRIPHENYLPHOSPHINE-CONTAINING COATINGS WITH ENHANCED ADHESION TO UNPRIMED SURFACES | SHEBOYGAN PAINT COMPANY (US) | 2022-10-06 | — | — | WO | disclosed |
| US-9200009-B2 | Polycyclic pyridone derivative having integrase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2015-12-01 | — | — | US | disclosed |
| US-20140256937-A1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2014-09-11 | — | — | US | disclosed |
| US-8716368-B2 | Unsaturated polyester resin or vinyl ester resin composition | DSM IP ASSETS B.V. (NL) | 2014-05-06 | — | — | US | disclosed |
| US-8211967-B2 | Composite repair resins containing minimal hazardous air pollutants and volatile organic compound | DREXEL UNIVERSITY (US) | 2012-07-03 | — | — | US | disclosed |
| US-20120041124-A1 | COMPOSITE REPAIR RESINS CONTAINING MINIMAL HAZARDOUS AIR POLLUTANTS AND VOLATILE ORGANIC COMPOUND | DREXEL UNIVERSITY (US) | 2012-02-16 | — | — | US | disclosed |
| US-4411899-A | Substituted derivatives of amino alkane diols as gastric secretion inhibitors | MERCK & CO., INC. (US) | 1983-10-25 | — | — | US | disclosed |
| EP-0082376-A2 | Substituted derivatives of amino alkane diols as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1983-06-29 | — | — | EP | disclosed |
| EP-0059903-A1 | Diaminooxadiazoles, their use as gastric secretion inhibitors, and process for their preparation | MERCK & CO. INC. (US) | 1982-09-15 | — | — | EP | disclosed |
| EP-0040696-A2 | Aminothiadiazoles as gastric secretion inhibitors | MERCK & CO. INC. (US) | 1981-12-02 | — | — | EP | disclosed |
| US-4293616-A | CELLULOSE, MASONRY, CURING | GENERAL ELECTRIC COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4247445-A | ROOM-TEMPERATURE VULCANIZABLE SILICONE RUBBER COMPRISING A POLYSILOXANE, CALCIUM CARBONATE, ACYLOXYSILANE, AND CATALYST | GENERAL ELECTRIC COMPANY (US) | 1981-01-27 | — | — | US | disclosed |
| US-4101602-A | COATINGS | THE GENERAL TIRE & RUBBER COMPANY (US) | 1978-07-18 | — | — | US | disclosed |
| US-4061845-A | PROTECTIVE OR DECORATIVE COATINGS FOR BONDERIZED STEEL | THE GENERAL TIRE & RUBBER COMPANY (US) | 1977-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256937-A1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY | TYMP, CDK6, IMPA1 | LMNA 1344/4885CYP19A1 1072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.