Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methyprylon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyprylon SCHEMBL155839 | 0.91 | LMNA (0.40) | LMNACYP19A1 | |
| Methyprylon SCHEMBL155838 | 0.91 | LMNA (0.40) | LMNACYP19A1 | |
| Methyprylon SCHEMBL9014931 | 0.90 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL8663851 | 0.85 | LMNA (0.33) | LMNACYP19A1 | |
| Methyprylon SCHEMBL6695974 | 0.83 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL8665659 | 0.72 | — | — | |
| Barbital SCHEMBL129289 | 0.66 | LMNA (0.77) | LMNA | |
| SCHEMBL19078047 | 0.58 | HTT (0.33) | — | |
| SCHEMBL16924883 | 0.58 | LMNA (0.50) | LMNA | |
| SCHEMBL18136080 | 0.57 | NAAA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |
| WO-2000018396-A1 | HMG-CoA REDUCTASE INHIBITOR-CONTAINING PREPARATIONS | SANKYO COMPANY, LIMITED (JP) | 2000-04-06 | — | — | WO | disclosed |
| US-4782149-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVES | HOFFMAN-LA ROCHE INC. (US) | 1988-11-01 | — | — | US | disclosed |