Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14940936 | 0.83 | ALDH1A1 (0.64) | CHRM4MAPTALDH1A1POLBCRHBP | |
| SCHEMBL11638229 | 0.83 | MEN1 (0.44) | MAPTALDH1A1SMN1; SMN2MAPK1ACHE | |
| SCHEMBL21164657 | 0.79 | ALDH1A1 (0.62) | CHRM4MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL13651289 | 0.79 | AR (0.50) | CHRM4MAPT | |
| SCHEMBL13908428 | 0.78 | NR3C1 (0.47) | MAPTMAPK1ACHENR3C1LMNA | |
| SCHEMBL4981272 | 0.74 | PDE4B (0.57) | MAPTALDH1A1MAPK1LMNA | |
| SCHEMBL7303075 | 0.74 | ALDH1A1 (0.65) | MAPTALDH1A1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL28449799 | 0.74 | HTR2C (0.40) | MAPTALDH1A1SMN1; SMN2MAPK1HTR2C | |
| SCHEMBL28403533 | 0.73 | HRH3 (0.53) | MAPTALDH1A1SMN1; SMN2MAOAMAOB | |
| SCHEMBL15160573 | 0.73 | HRH3 (0.55) | MAPTALDH1A1SMN1; SMN2MAPK1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007087-A2 | SUBSTITUTED (HETEROCYCLOALKYL)METHYL AZOLE DERIVATIVES AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |