SCHEMBL6237565

SCHEMBL6237565

O=C(O)CC1=Nc2ccc(I)cc2S(=O)(=O)N1

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.31
CA12 O43570 1/20 0.31
CA4 P22748 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6235954 0.84 CA2 (0.40) CA2CA12CA4CA7CA9
SCHEMBL6232214 0.83 CA2 (0.39) CA2CA12CA4CA7CA9
SCHEMBL6237560 0.80 CA12 (0.39) CA2CA12CA4CA7CA9
SCHEMBL20777728 0.78 CA2 (0.36) CA2CA12CA4CA7CA9
SCHEMBL20773655 0.71 GABRA2 (0.43) CA2CA12CA7CA9CA1
SCHEMBL335046 0.70 ALDH1A1 (0.45)
SCHEMBL24086559 0.70 RAB9A (0.41) CA2CA12CA9CA1
SCHEMBL20777651 0.68 GABRA1 (0.33) CA2CA1
SCHEMBL20777868 0.67 NPC1 (0.44)
SCHEMBL20777843 0.67 GAA (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401443-A4 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORP (US) 2005-10-26 EP disclosed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 US disclosed
EP-1401443-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2004-03-31 EP disclosed
WO-2002098424-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2002-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147739-A1 Novel anti-infectives RPL5, RPL7, RPL35 CA2 4750/4885CA12 4222/4885CA4 4527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.