SCHEMBL6237705

SCHEMBL6237705

Cc1ccc(COCCNCC(N)=O)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.45
NPC1 O15118 2/20 0.45
PARP10 Q53GL7 1/20 0.43
ALDH1A1 P00352 2/20 0.41
MAPT P10636 1/20 0.41
MAPK1 P28482 1/20 0.41
AGXT P21549 2/20 0.41
SPHK2 Q9NRA0 1/20 0.40
SPHK1 Q9NYA1 1/20 0.40
S1PR1 P21453 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
CACNA1F O60840 1/20 0.38
TACR1 P25103 1/20 0.38
CACNA1D Q01668 1/20 0.38
CACNA1S Q13698 1/20 0.38
CACNA1C Q13936 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6237097 0.85 LMNA (0.48) RAB9ANPC1AGXTSPHK2SPHK1
SCHEMBL6239312 0.84 SMN1; SMN2 (0.52) RAB9ANPC1PARP10SPHK2SPHK1
SCHEMBL6235212 0.78 IDO1 (0.45) RAB9ANPC1MAPK1SMN1; SMN2
SCHEMBL6237709 0.78 DRD2 (0.47) RAB9ANPC1AGXTCA1CA2
Trifluoroacetic Acid SCHEMBL7760506 0.77 SMN1; SMN2 (0.46) SPHK2SPHK1CACNA1FTACR1CACNA1D
SCHEMBL6237592 0.77 MAOB (0.40) ALDH1A1MAPTSPHK2SPHK1MAOB
SCHEMBL21900580 0.76 PARP10 (0.46) RAB9ANPC1PARP10ALDH1A1MAPT
SCHEMBL14410387 0.76 KDM4E (0.49) RAB9ANPC1ALDH1A1MAPK1MAOB
SCHEMBL6237989 0.75 IDO1 (0.49) ALDH1A1AGXTSPHK2SPHK1HTT
SCHEMBL21664684 0.75 RAB9A (0.54) RAB9ANPC1PARP10ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005011697-A2 SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B ASTEX THERAPEUTICS LIMITED (GB) 2005-02-10 WO disclosed