Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | STS | P08842 | 12/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL6238010 | 1.00 | KDM4E (0.68) | KDM4ESTSABCC4CA1CA2 | |
| SCHEMBL5154685 | 0.86 | LMNA (0.64) | KDM4ESTSABCC4CA1CA2 | |
| SCHEMBL5682148 | 0.86 | LMNA (0.64) | KDM4ESTSABCC4CA1CA2 | |
| SCHEMBL1246984 | 0.86 | LMNA (0.64) | KDM4ESTSABCC4CA1CA2 | |
| SCHEMBL5679838 | 0.86 | LMNA (0.64) | KDM4ESTSABCC4CA1CA2 | |
| SCHEMBL5679791 | 0.86 | LMNA (0.64) | KDM4ESTSABCC4CA1CA2 | |
| SCHEMBL4284331 | 0.83 | LMNA (0.67) | KDM4ESTSABCC4ABCC1CYP2C9 | |
| SCHEMBL1246985 | 0.83 | LMNA (0.67) | KDM4ESTSABCC4ABCC1CYP2C9 | |
| Estrone Sulfuric Acid SCHEMBL939946 | 0.81 | KDM4E (1.00) | KDM4ESTSABCC4CA1CA2 | |
| Estrone Sulfuric Acid SCHEMBL8901903 | 0.81 | KDM4E (1.00) | KDM4ESTSABCC4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1251856-B1 | METHOD OF INCREASING ALERTNESS BY ADMINISTRATION OF A VOMEROPHERIN, AND VOMEROPHERIN-EMITTING ALARM DEVICES | PHERIN PHARM INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6544971-B1 | Alarm device especially for detecting fires, unauthorized entry or sleep apnea, or the presence of CO, CH4, propane or radon | PHERIN PHARMACEUTICALS, INC. | 2003-04-08 | — | — | US | disclosed |
| EP-1251856-A1 | METHOD OF INCREASING ALERTNESS BY ADMINISTRATION OF A VOMEROPHERIN, AND VOMEROPHERIN-EMITTING ALARM DEVICES | Pherin Pharmaceuticals, Inc. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001056577-A1 | METHOD OF INCREASING ALERTNESS BY ADMINISTRATION OF A VOMEROPHERIN, AND VOMEROPHERIN-EMITTING ALARM DEVICES | PHERIN PHARMACEUTICALS, INC. (US) | 2001-08-09 | — | — | WO | disclosed |