Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625331 | 0.88 | PIM1 (0.45) | JAK2JAK3PTK2GPR119SCN9A | |
| SCHEMBL624058 | 0.85 | JAK2 (0.47) | JAK2JAK3PTK2USP30TGFBR1 | |
| SCHEMBL624433 | 0.83 | FYN (0.47) | JAK2JAK3PTK2USP30TGFBR1 | |
| SCHEMBL624904 | 0.81 | F2RL3 (0.41) | JAK2JAK3PTK2KDM4EHSD17B10 | |
| SCHEMBL627188 | 0.80 | GPR119 (0.40) | GPR119LIMK2KDM4EHPGDMAPT | |
| SCHEMBL628029 | 0.72 | F2RL3 (0.49) | TGFBR1GPR119SCN9AKDM4EMEN1 | |
| SCHEMBL626983 | 0.72 | CETP (0.44) | JAK2JAK3PTK2GPR119KDM4E | |
| SCHEMBL625330 | 0.71 | PIM1 (0.52) | — | |
| SCHEMBL624533 | 0.71 | PIM1 (0.53) | KDM4EMAPTPKM | |
| SCHEMBL624009 | 0.70 | PIM1 (0.44) | GAAMAPTF2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |