Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.40 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30198077 | 0.87 | MAPT (0.44) | MAPTKMT2AKMOMETALDH1A1 | |
| SCHEMBL24054541 | 0.87 | MAPT (0.44) | MAPTKMT2AKMOMETALDH1A1 | |
| SCHEMBL6236333 | 0.83 | L3MBTL1 (0.44) | MAPTKMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL6231590 | 0.82 | MAPT (0.40) | MAPTKMT2AKMOMETALDH1A1 | |
| SCHEMBL6234062 | 0.82 | DNM1 (0.40) | MAPTKMT2AALDH1A1NPC1POLB | |
| SCHEMBL6738246 | 0.82 | ALDH1A1 (0.40) | MAPTKMT2AKMOALDH1A1KDM4E | |
| SCHEMBL6232591 | 0.82 | NOS3 (0.41) | MAPTKMT2AKMOALDH1A1KDM4E | |
| SCHEMBL6738655 | 0.81 | MYLK (0.52) | MAPTKMT2AKMOMETALDH1A1 | |
| SCHEMBL5308775 | 0.78 | ALDH1A1 (0.55) | MAPTKMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL29811358 | 0.78 | MAPT (0.53) | MAPTKMT2AALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401443-A4 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1401443-A1 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002098424-A1 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-12 | — | — | WO | disclosed |