SCHEMBL6239249

SCHEMBL6239249

Cc1cc(C(O)(CN)C(F)(F)F)ccc1NC(=O)OC(C)(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
RXFP1 Q9HBX9 1/20 0.40
CISD2 Q8N5K1 1/20 0.39
ABCC9 O60706 2/20 0.38
ABCC8 Q09428 2/20 0.38
KCNJ11 Q14654 2/20 0.38
KCNJ8 Q15842 2/20 0.38
KDM4E B2RXH2 1/20 0.38
LMNA P02545 1/20 0.38
MAPK1 P28482 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
CCR2 P41597 1/20 0.37
MAPT P10636 1/20 0.37
POLB P06746 1/20 0.37
ATM Q13315 1/20 0.37
KCNQ4 P56696 1/20 0.37
KCNQ5 Q9NR82 1/20 0.37
PDK1 Q15118 1/20 0.36
PDK2 Q15119 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6371341 0.84 ABCC9 (0.42) SMN1; SMN2ABCC9ABCC8KCNJ11KCNJ8
SCHEMBL7667607 0.82 RXFP1 (0.55) SMN1; SMN2RXFP1CISD2LMNAMEN1
SCHEMBL29803307 0.82 RXFP1 (0.55) SMN1; SMN2RXFP1CISD2LMNAMEN1
SCHEMBL5151689 0.80 ALDH1A1 (0.44) SMN1; SMN2RXFP1KDM4ELMNAMAPK1
SCHEMBL6243514 0.80 RXFP1 (0.41) SMN1; SMN2RXFP1CISD2ABCC9ABCC8
SCHEMBL6237368 0.80 CYP1A2 (0.41) SMN1; SMN2RXFP1ABCC9ABCC8KCNJ11
SCHEMBL29803357 0.79 SMN1; SMN2 (0.47) SMN1; SMN2RXFP1CISD2LMNAMEN1
SCHEMBL18703070 0.79 SMN1; SMN2 (0.47) SMN1; SMN2RXFP1CISD2LMNAMEN1
SCHEMBL5154485 0.78 SMN1; SMN2 (0.43) SMN1; SMN2RXFP1ABCC9ABCC8KCNJ11
SCHEMBL8297312 0.75 SMN1; SMN2 (0.63) SMN1; SMN2CISD2LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050250822-A1 Substituted benzanilide compound and noxious organism controlling agent NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2005-11-10 US disclosed
EP-1538138-A1 SUBSTITUTED BENZANILIDE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 2005-06-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050250822-A1 Substituted benzanilide compound and noxious organism controlling agent GCN1, L3MBTL3, L3MBTL4 SMN1; SMN2 2208/4885RXFP1 3191/4885CISD2 3723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.