SCHEMBL6242511

SCHEMBL6242511

COc1ccc(-c2cc(=O)c3c(O)c(O)c(O)cc3o2)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.81
FLT3 P36888 6/20 0.81
MEN1 O00255 6/20 0.81
MAPT P10636 6/20 0.81
NPC1 O15118 5/20 0.81
RAB9A P51151 3/20 0.81
POLB P06746 3/20 0.81
KIT P10721 1/20 0.81
NFKB1 P19838 1/20 0.81
OPRD1 P41143 1/20 0.81
NFKB2 Q00653 1/20 0.81
RELA Q04206 1/20 0.81
MAOB P27338 2/20 0.76
CYP19A1 P11511 1/20 0.76
CYP1A1 P04798 3/20 0.72
CYP1B1 Q16678 3/20 0.72
GABRP O00591 3/20 0.72
GABRD O14764 3/20 0.72
GABRA1 P14867 3/20 0.72
GABRB1 P18505 3/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504103 0.90 FLT3 (0.81) KMT2AFLT3MEN1MAPTNPC1
Pectolinarigenin SCHEMBL243686 0.90 MAPT (1.00) KMT2AFLT3MEN1MAPTNPC1
Pectolinarigenin SCHEMBL29606971 0.90 MAPT (1.00) KMT2AFLT3MEN1MAPTNPC1
SCHEMBL28732976 0.90 FLT3 (0.81) KMT2AFLT3MEN1MAPTNPC1
Ladanein SCHEMBL737069 0.88 FLT3 (0.81) KMT2AFLT3MEN1MAPTNPC1
SCHEMBL16521507 0.88 MAPT (0.71) KMT2AFLT3MEN1MAPTNPC1
Scutellarein SCHEMBL23854870 0.88 KMT2A (0.89) KMT2AFLT3MEN1MAPTNPC1
SCHEMBL28592818 0.88 MAPT (0.74) KMT2AFLT3MEN1MAPTNPC1
SCHEMBL10001096 0.86 FLT3 (0.72) KMT2AFLT3MEN1MAPTNPC1
SCHEMBL19303535 0.86 FLT3 (0.69) KMT2AFLT3MEN1MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114306317-A Application of scutellarein methylated derivative in preparation of medicine for preventing and/or treating novel coronavirus 复旦大学 2022-04-12 CN claimed
WO-2005020881-A2 COMPOSITIONS OF FLAVONOIDS AND FLAVONOID-CONTAINING EXTRACTS AND THE TREATMENT OF DISEASES SHANGHAI COMMAN PHARMACEUTICAL CO. (US) 2005-03-10 WO claimed
US-20050049206-A1 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases SHANGHAI COMMAN PHARMACEUTICAL CO. LTD. (CN) 2005-03-03 US claimed
EP-4580594-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS AnalytiCon Discovery - Zweigniederlassung der BRAIN Biotech AG (DE) 2025-07-09 EP disclosed
WO-2024046834-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS ANALYTICON DISCOVERY GMBH (DE) 2024-03-07 WO disclosed
EP-4331564-A1 ANTIOXIDANT COMPOSITION COMPRISING 5-DEOXYFLAVONOIDS Analyticon Discovery GmbH (DE) 2024-03-06 EP disclosed
CN-114306317-A Application of scutellarein methylated derivative in preparation of medicine for preventing and/or treating novel coronavirus 复旦大学 2022-04-12 CN disclosed
US-10744114-B2 Use of eupatilin as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity OSTEONEUROGEN INC. (KR) 2020-08-18 US disclosed
US-10744113-B2 Use of chromone derivative as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity OSTEONEUROGEN INC. (KR) 2020-08-18 US disclosed
US-20190231739-A1 NEW USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY OSTEONEUROGEN INC. (KR) 2019-08-01 US disclosed
EP-2868657-B1 METHOD FOR PREPARING HIGH PURITY SCUTELLARIN AGLYCONE KPC PHARMACEUTICALS INC (CN) 2017-08-30 EP disclosed
US-20170239211-A1 USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY OSTEONEUROGEN INC. (KR) 2017-08-24 US disclosed
US-20170239211-A1 USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY OSTEONEUROGEN INC. (KR) 2017-08-24 US disclosed
US-20120029066-A1 USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS TAIPEI MEDICAL UNIVERSITY (TW) 2012-02-02 US disclosed
US-20120029066-A1 USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS TAIPEI MEDICAL UNIVERSITY (TW) 2012-02-02 US disclosed
US-20050049206-A1 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases SHANGHAI COMMAN PHARMACEUTICAL CO. LTD. (CN) 2005-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190231739-A1 NEW USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY CDH1, SMAD3, SMAD2 KMT2A 3011/4885FLT3 4672/4885MEN1 2220/4885
US-10744113-B2 Use of chromone derivative as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity CDH1, SMAD3, SMAD2 KMT2A 2795/4885FLT3 4706/4885MEN1 1939/4885
US-20050049206-A1 Compositions of flavonoids and flavonoid-containing extracts and the treatment of diseases FNTA, COLGALT1, F3 KMT2A 4107/4885FLT3 4440/4885MEN1 4807/4885
US-20170239211-A1 USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT INHIBITORY ACTIVITY CDH1, SMAD3, SMAD2 KMT2A 2795/4885FLT3 4706/4885MEN1 1939/4885
US-20120029066-A1 USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS HTR2C, GRIN2C, HTR5A KMT2A 1058/4885FLT3 3391/4885MEN1 4859/4885
US-10744114-B2 Use of eupatilin as pharmaceutical composition for prevention and treatment of fibrosis using EMT inhibitory activity SMAD2, CDH1, SMAD3 KMT2A 3821/4885FLT3 4853/4885MEN1 757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.