Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.44 |
| ▸ | RXRB | P28702 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL29663592 | 1.00 | RAB9A (0.46) | RAB9AKMT2ARXRARXRBMCL1 | |
| SCHEMBL128622 | 0.85 | RXRA (0.57) | KMT2ARXRARXRBKDM4EALDH1A1 | |
| Salicylic Acid SCHEMBL28505679 | 0.76 | ALDH1A1 (0.55) | RAB9AKMT2ARXRARXRBKDM4E | |
| Salicylic Acid SCHEMBL5874177 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL19717848 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL15717117 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL5313430 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL15847 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL1904685 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD | |
| Salicylic Acid SCHEMBL10788832 | 0.76 | KDM4E (0.67) | KMT2AMCL1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037239-A2 | USE OF A COMPOUND FROM THE GROUP OF HETERODIAZOLES OR A SALT OF SAID COMPOUND, COSMETIC OR THERAPEUTIC FORMULATION CONTAINING SAID COMPOUND OR SALT, SAID COMPOUND OR SALT AS A THERAPEUTIC AGENT, AND SAID SALT | SYMRISE GMBH & CO. KG (DE) | 2005-04-28 | — | — | WO | disclosed |