Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 4/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20212343 | 0.81 | ADCY10 (0.52) | IDO1LMNAKDM4EPNPADCY10 | |
| SCHEMBL1748845 | 0.80 | ALDH1A1 (0.53) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL625229 | 0.75 | CYP1A2 (0.44) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL29770374 | 0.75 | DHPS (0.58) | EDNRBEDNRA | |
| SCHEMBL618135 | 0.75 | DHPS (0.58) | EDNRBEDNRA | |
| SCHEMBL20212189 | 0.73 | NPSR1 (0.59) | PNPADCY10 | |
| SCHEMBL855710 | 0.72 | ALDH1A1 (0.44) | TSHRCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8329979 | 0.71 | SMN1; SMN2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL1442342 | 0.71 | L3MBTL1 (0.66) | HSD17B10ALOX15ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL27868745 | 0.71 | ALDH1A1 (0.40) | TSHRALDH1A1LMNAMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603497-B1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | MEGAFINE PHARMA P LTD (IN) | 2018-08-08 | — | — | EP | disclosed |
| US-9139537-B2 | Process for preparation of bosentan | MEGAFINE PHARMA(P) LTD. (IN) | 2015-09-22 | — | — | US | disclosed |
| US-20130296560-A1 | Novel Process For Preparation Of Bosentan | MEGAFINE PHARMA (P) LTD. (IN) | 2013-11-07 | — | — | US | disclosed |
| WO-2013136110-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN MONOHYDRATE | NATCO PHARMA LIMITED (IN) | 2013-09-19 | — | — | WO | disclosed |
| US-20130245259-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN MONOHYDRATE | NATCO PHARMA LIMITED (IN) | 2013-09-19 | — | — | US | disclosed |
| EP-2603497-A1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | Megafine Pharma (P) Ltd. (IN) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020421-A1 | A NOVEL PROCESS FOR PREPARATION OF BOSENTAN | MEGAFINE PHARMA (P) LTD. (IN) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245259-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN MONOHYDRATE | VASP, EDNRB, PTGIR | TSHR 3425/4885CYP1A2 211/4885CYP3A4 51/4885 |
| US-20130296560-A1 | Novel Process For Preparation Of Bosentan | BMP6, EDNRB, PAH | TSHR 1243/4885CYP1A2 1617/4885CYP3A4 629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.