SCHEMBL6252633 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	CTSS	P25774	12/20	0.40

▸	CTSL	P07711	10/20	0.40

▸	CTSB	P07858	6/20	0.40

▸	CTSK	P43235	3/20	0.39

▸	ATM	Q13315	2/20	0.39

▸	HTR2C	P28335	2/20	0.35

▸	HTR2A	P28223	1/20	0.35

▸	HTR2B	P41595	1/20	0.35

▸	EGLN2	Q96KS0	1/20	0.35

▸	EGLN1	Q9GZT9	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6250919	0.90	ATM (0.41)	CTSSCTSLCTSBATMHTR2C
SCHEMBL6252579	0.89	ATM (0.40)	CTSSCTSLCTSBATMHTR2C
SCHEMBL6254005	0.86	ATM (0.41)	CTSSCTSLCTSBATMHTR2C
SCHEMBL6253366	0.86	MTNR1A (0.47)	ATMHTR2CHTR2AHTR2B
SCHEMBL3965535	0.82	HTR2C (0.45)	CTSSCTSLCTSBCTSKATM
SCHEMBL6251561	0.82	ATM (0.40)	ATM
SCHEMBL6255885	0.80	ALDH1A1 (0.42)	ATM
SCHEMBL5796714	0.75	MAPK1 (0.38)	CTSSCTSLCTSBCTSKATM
SCHEMBL6255179	0.74	MAPK1 (0.38)	CTSSCTSLCTSBCTSKATM
SCHEMBL7009702	0.73	KMO (0.44)	CTSSCTSLCTSBCTSKATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2005053688-A1	SUBSTITUTED FURO[2,3-G] INDAZOLES FOR THE TREATMENT OF GLAUCOMA	ALCON, INC. (CH)	2005-06-16	—	—	WO	disclosed