Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3960196 | 0.85 | ALDH1A1 (0.43) | ALDH1A1LMNAKDM4EPOLBGLA | |
| SCHEMBL6250919 | 0.82 | ATM (0.41) | ALDH1A1LMNAKDM4EHPGDMAPT | |
| SCHEMBL6252579 | 0.82 | ATM (0.40) | ALDH1A1LMNAKDM4EHPGDMAPT | |
| SCHEMBL6253366 | 0.81 | MTNR1A (0.47) | ALDH1A1HPGDMAPTCYP2D6CYP2C9 | |
| SCHEMBL6252633 | 0.80 | CTSS (0.40) | ATM | |
| SCHEMBL6254005 | 0.79 | ATM (0.41) | ALDH1A1LMNAKDM4EHPGDMAPT | |
| SCHEMBL3966087 | 0.76 | HTR2C (0.57) | ALDH1A1LMNAKDM4EPOLBGLA | |
| SCHEMBL6251561 | 0.75 | ATM (0.40) | ALDH1A1LMNAKDM4EPOLBHPGD | |
| SCHEMBL6257465 | 0.69 | MAPK1 (0.39) | LMNAMAPTSMN1; SMN2ATMTP53 | |
| SCHEMBL6252719 | 0.69 | MAPK1 (0.39) | LMNAMAPTSMN1; SMN2ATMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053688-A1 | SUBSTITUTED FURO[2,3-G] INDAZOLES FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2005-06-16 | — | — | WO | disclosed |