Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6250919 | 0.92 | ATM (0.41) | ATMHTR2CHTR2AHTR2BPTPN1 | |
| SCHEMBL6254005 | 0.90 | ATM (0.41) | ATMHTR2CHTR2APTPN1MAOB | |
| SCHEMBL6252633 | 0.89 | CTSS (0.40) | ATMHTR2CHTR2AHTR2BCTSL | |
| SCHEMBL6253366 | 0.88 | MTNR1A (0.47) | ATMHTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL6251561 | 0.86 | ATM (0.40) | ATMMAOBMAOALMNAKDM4E | |
| SCHEMBL6255885 | 0.82 | ALDH1A1 (0.42) | ATMLMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL3967475 | 0.81 | HTR2C (0.49) | ATMHTR2CHTR2AHTR2BMEN1 | |
| SCHEMBL5796714 | 0.77 | MAPK1 (0.38) | ATMPTPN1LMNAHTTMAPK1 | |
| SCHEMBL6255179 | 0.76 | MAPK1 (0.38) | ATMPTPN1LMNAMAPK1CTSL | |
| SCHEMBL7009702 | 0.75 | KMO (0.44) | ATMHTR2CHTR2AHTR2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053688-A1 | SUBSTITUTED FURO[2,3-G] INDAZOLES FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2005-06-16 | — | — | WO | disclosed |