Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 19/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280669 | 1.00 | CASP1 (0.67) | CASP1 | |
| SCHEMBL8085967 | 0.92 | CASP1 (0.66) | CASP1 | |
| SCHEMBL7166866 | 0.92 | CASP1 (0.66) | CASP1 | |
| SCHEMBL732093 | 0.92 | CASP1 (0.66) | CASP1 | |
| SCHEMBL28968911 | 0.91 | CASP1 (0.62) | CASP1 | |
| SCHEMBL6261373 | 0.91 | CASP1 (0.62) | CASP1 | |
| SCHEMBL13724740 | 0.91 | CASP1 (0.64) | CASP1 | |
| SCHEMBL19695419 | 0.91 | CASP1 (0.64) | CASP1 | |
| SCHEMBL1067460 | 0.91 | CASP1 (0.64) | CASP1 | |
| SCHEMBL554032 | 0.91 | CASP1 (0.67) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12473331-B2 | Macrocyclic compounds as proteasome inhibitors | CORNELL UNIVERSITY (US) | 2025-11-18 | — | — | US | disclosed |
| US-20250152658-A1 | CYCLIC PEPTIDE FOR TRAPPING INTERLEUKIN-1 BETA | MERCK SHARP & DOHME LLC (US) | 2025-05-15 | — | — | US | disclosed |
| EP-3538526-B1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2024-04-10 | — | — | EP | disclosed |
| US-20240043470-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS | UNIV CORNELL (US) | 2024-02-08 | — | — | US | disclosed |
| US-11834515-B2 | Macrocyclic compounds as proteasome inhibitors | CORNELL UNIVERSITY (US) | 2023-12-05 | — | — | US | disclosed |
| CN-117165967-A | Method for photoelectrochemical synthesis of alkenyl-containing unnatural amino acid derivative | 中国科学院化学研究所 | 2023-12-05 | — | — | CN | disclosed |
| WO-2023228177-A1 | COMPOSITIONS COMPRISING ASPACYTARABINE AND ADDITIONAL COMPOUNDS, AND USE THEREOF | BIOSIGHT LTD. (IL) | 2023-11-30 | — | — | WO | disclosed |
| CN-116829523-A | Phenol derivative, crystal form and preparation method thereof | 天地恒一制药股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2023143158-A1 | PHENOL DERIVATIVE, CRYSTAL FORM THEREOF, AND PREPARATION METHOD THEREFOR | 天地恒一制药股份有限公司 | 2023-08-03 | — | — | WO | disclosed |
| CN-116059390-A | Prodrugs of cytotoxic actives with enzymatically cleavable groups | 拜耳制药股份公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-112294972-A | PSMA activated antitumor prodrug CPT-Y and preparation method and application thereof | 薪火炙药(北京)科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| EP-3694508-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS | Cornell University (US) | 2020-08-19 | — | — | EP | disclosed |
| WO-2020127168-A1 | HERBICIDAL CINNOLINIUM COMPOUNDS | SYNGENTA CROP PROTECTION AG (CH) | 2020-06-25 | — | — | WO | disclosed |
| US-20190270741-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-05 | — | — | US | disclosed |
| WO-2019075259-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS | CORNELL UNIVERSITY (US) | 2019-04-18 | — | — | WO | disclosed |
| CN-108025084-A | Antibody Drug Conjugates (ADC) and antibody prodrug conjugates (APDC) with enzyme cleavable groups | 拜耳医药股份有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-107921146-A | Spindle drives the antibody drug conjugate (ADC) of albumen (KSP) inhibitor and the antibody of anti-CD123 | 拜耳医药股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107635586-A | The antibody drug conjugate (ADC) of KSP inhibitor and not glycosyafated anti-TWEAKR antibody | 拜耳医药股份有限公司 | 2018-01-26 | — | — | CN | disclosed |
| WO-2017165416-A1 | PROTECTED DERIVATIVES OF 2-AMINO-4-PHOSPHOBUTANOIC ACID | AGENUS INC. (US) | 2017-09-28 | — | — | WO | disclosed |
| WO-2009151621-A1 | SUBSTITUTED (1, 2, 4-0XADIAZ0L-3-YL) INDOLIN-1-YL CARBOXYLIC ACID DERIVATIVES USEFUL AS S1P1 AGONISTS | ARENA PHARMACEUTICALS, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043470-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS | PSMB5, PSMB1, PSMB3 | CASP1 1059/4885 |
| US-20190270741-A1 | CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS | ITGB1, ITGAV, ITGA1 | CASP1 2507/4885 |
| US-11834515-B2 | Macrocyclic compounds as proteasome inhibitors | PSMB5, PSMB1, PSMB3 | CASP1 1059/4885 |
| US-12473331-B2 | Macrocyclic compounds as proteasome inhibitors | PSMB5, PSMB1, PSMB3 | CASP1 1059/4885 |
| US-20250152658-A1 | CYCLIC PEPTIDE FOR TRAPPING INTERLEUKIN-1 BETA | IL1R1, IL1A, IL1B | CASP1 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.