SCHEMBL625445

SCHEMBL625445

Nc1nc(=O)n([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)cc1I

nearest known ligand 0.74

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 10/20 0.62
P2RY6 Q15077 8/20 0.59
P2RY4 P51582 5/20 0.59
ENPP1 P22413 2/20 0.57
P2RY1 P47900 2/20 0.57
P2RX1 P51575 1/20 0.57
P2RX3 P56373 1/20 0.57
P2RY11 Q96G91 1/20 0.57
P2RX4 Q99571 1/20 0.57
P2RY12 Q9H244 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3503039 1.00 P2RY2 (0.62) P2RY2P2RY6P2RY4ENPP1P2RY1
SCHEMBL17809091 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL16489876 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL903023 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL3469888 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL5501347 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL17789098 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL14946156 0.90 P2RY2 (0.55) P2RY2P2RY6P2RY4P2RY1P2RY11
SCHEMBL17979612 0.89 P2RY2 (0.64) P2RY2P2RY6P2RY4ENPP1P2RY1
SCHEMBL30166483 0.89 P2RY2 (0.64) P2RY2P2RY6P2RY4ENPP1P2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1382 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression CureVac SE (DE) 2025-11-04 US claimed
US-20250136711-A1 SEMENOGELIN NEUTRALIZING ANTIBODY AND EPITOPE AND APPLICATION THEREOF SHANGHAI BIOTROY BIOTECHNIQUE CO., LTD (CN) 2025-05-01 US claimed
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE TRANSLATE BIO INC (US) 2024-12-19 US claimed
CN-118924887-A HPV MRNA LNP vaccine 南京吉迈生物技术有限公司 2024-11-12 CN claimed
US-11998601-B2 Messenger RNA therapy for treatment of articular disease TRANSLATE BIO, INC. (US) 2024-06-04 US claimed
US-11980672-B2 Heterologous UTR sequences for enhanced mRNA expression MODERNATX, INC. (US) 2024-05-14 US claimed
US-11951120-B2 Modification of gene transcription and translation efficiency by 5′UTR sequence variation Nanjing GeneLeap Biotechnology Co., Ltd. 2024-04-09 US claimed
US-20230310484-A1 Modification of Gene Transcription and Translation Efficiency by 5'UTR Sequence Variation Nanjing GeneLeap Biotechnology Co., Ltd. (CN) 2023-10-05 US claimed
CN-116179549-A Modification of gene transcription and translation efficiency by 5' UTR sequence variants 南京吉迈生物技术有限公司 2023-05-30 CN claimed
US-20230050143-A1 Heterologous UTR Sequences for Enhanced mRNA Expression MODERNATX, INC. (US) 2023-02-16 US claimed
US-9234013-B2 Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded protein CUREVAC AG (DE) 2016-01-12 US claimed
US-20150184195-A1 ARTIFICIAL NUCLEIC ACID MOLECULES CUREVAC GMBH (DE) 2015-07-02 US claimed
US-20150165006-A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN Cure GmbH (DE) 2015-06-18 US claimed
US-20150093413-A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN CUREVAC GMBH (DE) 2015-04-02 US claimed
US-20120195936-A1 RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION ETHRIS GMBH (DE) 2012-08-02 US claimed
US-20100189729-A1 RNA-CODED ANTIBODY CURVAC GMBH (DE) 2010-07-29 US claimed
US-20100047261-A1 BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN CUREVAC GMBH (DE) 2010-02-25 US claimed
EP-2083851-A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN Curevac GmbH (DE) 2009-08-05 EP claimed
WO-2008052770-A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN CUREVAC GMBH (DE) 2008-05-08 WO claimed
US-20030039976-A1 Methods for base counting PE CORPORATION (NY) 2003-02-27 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230050143-A1 Heterologous UTR Sequences for Enhanced mRNA Expression RNGTT, UPF1, RNMT P2RY2 4412/4885P2RY6 4640/4885P2RY4 4672/4885
US-20150093413-A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN HNRNPH3, PARG, CPSF6 P2RY2 2733/4885P2RY6 2492/4885P2RY4 2512/4885
US-20150165006-A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN NASP, H1-5, PARG P2RY2 2266/4885P2RY6 1886/4885P2RY4 1986/4885
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression RNMT, NSUN3, RNGTT P2RY2 2992/4885P2RY6 2967/4885P2RY4 2730/4885
US-20100047261-A1 BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN RNMT, RNASE1, NSUN3 P2RY2 4516/4885P2RY6 4642/4885P2RY4 4740/4885
US-11980672-B2 Heterologous UTR sequences for enhanced mRNA expression RNGTT, UPF1, RNMT P2RY2 4412/4885P2RY6 4640/4885P2RY4 4672/4885
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE NSUN3, RNMT, TRDMT1 P2RY2 3741/4885P2RY6 3298/4885P2RY4 4107/4885
US-11998601-B2 Messenger RNA therapy for treatment of articular disease NSUN3, RNMT, TRDMT1 P2RY2 3741/4885P2RY6 3298/4885P2RY4 4107/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.