Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.39 |
| ▸ | HASPIN | Q8TF76 | 6/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627054 | 0.83 | KDM4E (0.48) | LMNATHRBTP53RXFP1 | |
| SCHEMBL23288616 | 0.76 | KCNH2 (0.45) | LMNATHRBKCNH2HASPINTP53 | |
| SCHEMBL626840 | 0.74 | FYN (0.30) | — | |
| SCHEMBL626842 | 0.74 | FYN (0.30) | — | |
| SCHEMBL627223 | 0.74 | MAPT (0.40) | LMNATHRBTP53RXFP1 | |
| SCHEMBL626886 | 0.73 | CKS1B (0.50) | LMNATP53 | |
| SCHEMBL627372 | 0.72 | PIK3CA (0.57) | KCNH2HASPINFLT3KITPIM1 | |
| SCHEMBL627087 | 0.72 | HASPIN (0.42) | LMNATHRBKCNH2HASPINFLT3 | |
| SCHEMBL627264 | 0.72 | CKS1B (0.43) | LMNATHRB | |
| SCHEMBL23268299 | 0.71 | LMNA (0.39) | LMNATHRBKCNH2HASPINFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |